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Organ Description Slot Effects Unlocked by
Sprite pickups organ 42

The Brain of Duke Theris

"The only remains of a despotic duke notorious for wielding ruthlessly brutal authority over the realms he controlled. His subjects eventually revolted and destroyed his body but kept his mind alive and imprisoned as punishment for his wicked reign."
Head
Max MP: +10

MP Regen: +0.2

Consume 20 brain organs
Sprite pickups organ 38

Fungal Fragment

“Some strange branching segment of an otherworldly fungus. It releases puffs of sweet smelling spores that heighten your senses."
Head
Damage: +0.1

Plague Damage: +10%

---
Sprite pickups organ 06

Gremulke's Fang

“The strange twinned tooth of an archaic demon lord. The dual points exude a sweet smelling venom.”
Head
Damage: +0.5

Move Speed: -10%

Kill 30 Gugs.
Sprite pickups organ 41

King Ermine's Brain

"The brain of a weak mided king who succumbed to a disease of spirtual consumption. His body became infested with otherworld spirits. In his most desperate hour, he endeavoured to have his brain removed from his body so that he could be free from the legion within him. Whether or not his identity survived is unknown."
Head
Max MP: +30
Consume 100 alien brain organs
Sprite pickups organ 45

Othello's Skull

"The jellied skull of the warlock, Othello. He was banished to the Fortress of Koth and was swallowed by the great beast trapped within. Rather than suffer a slow death by digestion, he focused his energies to his mind and was able to fortify a bastion of his being within. Little physically remains of his body except for a slimy shapeless skull."
Head
MP Regen: +0.4

Rate of Fire: -10%

Explore 7 layers of the Labyrinth of Ix
Sprite pickups organ 40

Queen Umvorax's Brain

"The brain of a queen who was obessed by material wealth. She practiced strange rituals to suffuse her body with gold and other precious ores. Her brain became saturated with gold."
Head
Luck: +4%

Max MP: +10

Dark Seeking: +20%

Dark Damage: +2

Black Eye: +20%

---
Sprite pickups organ 05

Saint Victor's Wisdom Tooth

"A large molar of a long forgotten saint. Actual records of his canonization have been lost, but legends say he was patron of lost and wretched."
Head
Max MP: +20
---
Sprite pickups organ 04

Shadow Hound Fang

"One of the large canines taken from a Shadow Hound, semi corporeal beasts bred by the Night Lords. Despite being bodily composed of shadow stuff, their teeth were undenaiably sharp."
Head
Fire Damage: +20%

Ice Damage: +20%

Break the cosmic seal holding this organ. (Kill a boss enemy and unlock the Planar Seals)
Sprite pickups organ samhainskull

Samhain Skull

"This skull has undergone ancient rituals of death and renewal. It;s visage strikes mortal fear into any who behold it."
Head
Your Fear effects also cause entropy damage over time.
Win the game as the fearful plant (Pumpkin Man)
Sprite pickups organ ennervatebrain

Ennervating Brain

"A bizarre brain with a mind of its own. You feel your spirit body quicken rapidly, but your ability to project magic power has slowed..."
Head
Damage: +0.1

Move Speed: +30%

Rate of Fire: -20%

Fire slowly, deal massive damage.

Defeat the third emissary within the Insanity Portal
Sprite pickups organ brainfrombeyond

Brain from Beyond

"A bizarre brain with a mind of its own. A pineal gland flails about on its ropy stalk. When you are hurt, you feel a rush of perception altering hormones."
Head
Enter a heightened state whenever you take damage.
Defeat the Master from within the Insanity Portal
Sprite pickups organ halfpumpkinskull

Half Pumpkin Skull

"Some strange skull with a half mask made of a rotting jack-o-lantern. It reeks of sweet mold and the skull cackles in a terrifying way."
Head
Fire a fearful bullet every 10 shots
---
Sprite pickups organ aggravatebrain

Aggravating Brain

"A bizarre brain with a mind of its own (albeit a weak one). It whispers inside your skull. You can feel your magic ability refocus on power over speed."
Head
Fire slowly, deal massive damage.
---
Sprite pickups organ brainfromafar

Brain from Afar

"A bizarre brain with a mind of its own (albeit a weak one). A small pineal gland reaches out on an extended tendril from within its fleshy coils."
Head
Fire in bursts, deal extra damage
---
Sprite pickups organ 15

Cyan Eye

"A seemingly normal humanoid eye which moves constantly, searching."
Head
Damage: +10%
---
Sprite pickups organ 16

Golden Eye

"A seemingly normal humanoid eye which seems slick and sweaty."
Head
Damage: +0.25
---
Sprite pickups organ 14

Magenta Eye

"A seemingly normal humanoid eye which is brittle and withered with age."
Head
Rate of Fire: +10%
---
Sprite pickups organ 18

Royal Blue Eye

"A seemingly normal humanoid eye, with a pupil from which light flashes out."
Head
Damage: +0.25
---
Sprite pickups organ 17

Ruddy Eye

"A thick, muscle bound humanoid eye which is, otherwise, seemingly normal."
Head
Damage: +10%
---
Sprite pickups organ 13

Viridian Eye

"A seemingly normal humanoid eye, however, the optic nerve and connective tissues move of their own volition."
Head
Rate of Fire: +10%
---
Sprite pickups organ 21

Cyan Cat Eye

"The eye of some large spectral feline. Its vertical iris allows it to see further in darkness. It searches desperately for something."
Head

Damage: +10%

MP Regen: +0.1

Dark Seeking; +10%

Explore 6 layers of an Ossein realm.
Sprite pickups organ 22

Golden Cat Eye

"The eye of some large spectral feline. Its vertical iris allows it to see further in darkness. Touching it fills you with breathlessness."
Head

Damage: +0.25

Fire Damage: +10%

Dark Seeking; +10%

Explore 6 layers of an Ossein realm.
Sprite pickups organ 20

Magenta Cat Eye

"The eye of some large spectral feline. Its vertical iris allows it to see further in darkness. It is exceedingly ancient and brittle."
Head

Rate of Fire: +10%

Plague Damage: +10%

Dark Seeking; +10%

Explore 6 layers of an Ossein realm.
Sprite pickups organ 24

Royal Blue Cat Eye

"The eye of some large spectral feline. Its vertical iris allows it to see further in darkness. You can catch sight of briefly appearing, glowing glyphs within its pupil."
Head

Damage: +0.25

Ice Damage: +10%

Dark Seeking; +10%

Explore 6 layers of an Ossein realm.
Sprite pickups organ 23

Ruddy Cat Eye

"The eye of some large spectral feline. Its vertical iris allows it to see further in darkness and the powerful ligaments give it a thick, steady appearance."
Head

Damage: +10%

Dark Seeking; +10%

Explore 6 layers of an Ossein realm.
Sprite pickups organ 19

Viridian Cat Eye

"The eye of some large spectral feline. Its vertical iris allows it to see further in darkness. It twitches in your palm, of its own accord."
Head

Rate of Fire: +20%

Dark Seeking; +10%

Explore 6 layers of an Ossein realm.
Sprite pickups organ 27

Cyan Starchild Eye

"The black eye of some far flung star thing. It has a bizarre cross shaped iris. It seems to absorb extra light and information about the space surrounding it."
Head

Damage: +10%

MP Regen: +0.2

Black Eye: +10%

Expanded Insight

Find your way to a lost realm...
Sprite pickups organ 28

Golden Starchild Eye

"The black eye of some far flung star thing. It has a bizarre cross shaped iris. It quivers with a high frequency vibration that numbs your fingertips."
Head

Damage: +0.25

Fire Damage: +10%

Black Eye: +10%

Expanded Insight

Find your way to a lost realm...
Sprite pickups organ 26

Magenta Starchild Eye

"The black eye of some far flung star thing. It has a bizarre cross shaped iris. You get a sense of power, ancient beyond words."
Head

Rate of Fire: +0.25

Plague Damage: +30%

Black Eye: +10%

Expanded Insight

Find your way to a lost realm...
Sprite pickups organ 30

Royal Blue Starchild Eye

"The black eye of some far flung star thing. It has an iris shaped in a bizarre facsimile of a dark run of power."
Head

Damage: +0.25

Ice Damage: +20%

Black Eye: +10%

Expanded Insight

Find your way to a lost realm...
Sprite pickups organ 29

Ruddy Starchild Eye

"The black eye of some far flung star thing. It has a bizarre cross shaped iris. The iris beats in time like a heart."
Head

Damage: +10%

Black Eye: +10%

Expanded Insight

Find your way to a lost realm...
Sprite pickups organ 25

Viridian Starchild Eye

"The black eye of some far flung star thing. It has a bizarre cross shaped iris. You can only guess at the purpose of such an alien organ."
Head

Rate of Fire: +20%

Black Eye: +10%

Expanded Insight

Find your way to a lost realm...
Sprite pickups organ starchildcataracteye

Starchild Cataract Eye

"A very old Starchild eye with a thick cataract in the center. While blind to the normal light spectrum, it may see unseen things..."
Head

Damage: +0.25

Rate of Fire: +10%

Max MP: +10

Expanded Insight

Find your way to a lost realm...
Sprite pickups organ observereye

Observer Eye

"The light focusing eye of a powerful Observer. A blinding energy radiates outward from within."
Head
Laser Damage: +30%
---
Sprite pickups organ 48

The Blueblood Hungry Heart

"A desperately hungry thing born of power and privilege. You fear it may overcome you in time."
Chest

Max HP: +1

Rate of Fire: -10%

MP Regen: +0.1

Find 1000 gold.
Sprite pickups organ 12

Bruised Tissue Mass

"A bruised and swollen organ that vaguely resembles a heart. It has somehow not only survived some unforgiving blunt trauma, but has been strengthened by the ordeal."
Chest

Max HP: +2

Damage: -0.1

Break the cosmic seal holding this organ. (Kill a boss enemy and unlock the Planar Seals)
Sprite pickups organ 35

The Brute's Lungs

"The lungs of amphibious gladiator beast known only as The Brute. Undefeated for centuries, he lavished in a life full of excess. Legends say that his private residence halls were filled with blood and that he would submerge himself within for weeks on end."
Chest
Damage: +10%
---
Sprite pickups organ 51

Butterfly Lung

"A strange alien organ that reminds you of a butterfly. It imbues your breath with a sweet pollen taste as it flaps rhythmically within your chest."
Chest

Rate of Fire: +10%

Move Speed: +5%

---
Sprite pickups organ 50

Caustic Heart

"An acid filled heart, pumping caustic bile instead of blood. You feel your body burning as you bring it close but desire the power it may bring you."
Chest

Max HP: +1

Damage: -0.25

Rate of Fire: -10%

Move Speed: -5%

Kill 200 Green Slimes.
Sprite pickups organ 39

Hermeth's Heart

"A shell encased heart once owned by the wizard, Hermeth. She made her home in the astral sea and learned the ways of the chitinous beings that dwell there. Her rituals and their knowledge enabled her to strengthen her body and fortify her vital organs with armored plates."
Chest
Max HP +1
---
Sprite pickups organ 47

The Hungry Heart

"A voracious thing that looks like it could devour a host from the inside out. It grins its teeth when you hold it close to your body."
Chest

Max HP: +1

Luck: +1%

Ingest 100 bits of healing energy (HP pickups)
Sprite pickups organ 44

Mandira's Heart

"The thorny pierced heart once owned by the wizard, Mandira. She was cursed by a spider venomancer to suffer a slow, painful demise. Her most powerful spells could not save her, but she encased the core essence of her soul within hr thorny heart so she could continue life as a shadow within."
Chest

Max HP: +1

Rate of Fire: +10%

Damage: -0.1

Break the cosmic seal holding this organ. (Kill a boss enemy and unlock the Planar Seals)
Sprite pickups organ 49

Nautiloid Heart

"A spiralling heart with a strange many chambered interior. Holding it close imparts to you a vauge memory of the ocean tides."
Chest

Max HP: +1

Rate of Fire: +10%

Break the cosmic seal holding this organ. (Kill a boss enemy and unlock the Planar Seals)
Sprite pickups organ 07

Snail Heart

"A weird organ resembling the body of a snail. Its actual vital purpose is unknown."
Chest

Max HP: +1

Ice Damage: +20%

Move Speed: -5%

Quaff (consume) 10 blood-thickening potions
Sprite pickups organ 46

Spice Fed Heart

"A heart saturated with exotic otherworld spices from centuries of exposure to strange trade between planes of existence. At some point it transcended normal organic function and began to hunger for the raw essences of magic."
Chest

Max HP: +2

MP Regen: -0.3

Move Speed: -5%

Break the cosmic seal holding this organ. (Kill a boss enemy and unlock the Planar Seals)
Sprite pickups organ 32

Star Thing's Heart

"The strange heart of some star thing from the great beyond. Its organic function is completely beyond your understanding. It feels brimming with unstable power."
Chest

Max HP: +1

Dark Damage: +1

Kill 50 Lesser Starchildren.
Sprite pickups organ 01

Tangled Heart

"A small, twisted thing. Could be the remains of a terrible accident, or a heartbroken lore. Something caused the thing to bind up and consume surrounding ribs."
Chest
Max HP: +1
---
Sprite pickups organ 34

Tumerichan's Lungs

"A sorceror and a spice merchant, Tumerichan was a legendary traveler of the outer realms. His life's work dealing in exotic trade goods left his lungs saturated and stained with psychoactive essence."
Chest

Luck: +1%

Fire Damage: +20%

---
Sprite pickups organ 36

Vembrax's Lungs

"The lungs of the arachnid demon witch, Vembrax. She enchanted her throat and lungs so that her breath was poison. She delighted in decimating foes with her demon song, her noxious breath and withering words working in double concert to guarantee the demise of her enemies."
Chest

Damage: +10%

Fire Damage: +10%

Break the cosmic seal holding this organ. (Kill a boss enemy and unlock the Planar Seals)
Sprite pickups organ 11

Yellowed Fatty Heart

"An oily organ that pumps otherwordly spice ichor instead of blood. You're surprised and unnerved at how natural the process feels."
Chest

Max HP: +1

MP Regen: -0.3

Break the cosmic seal holding this organ. (Kill a boss enemy and unlock the Planar Seals)
Sprite pickups organ modroncore

Modron Core

"A strange organ from the core of a modron. It whirrs and pulses with impeccable regularity."
Chest
Damage: +10%
---
Sprite pickups organ twinheart

Twin Heart

"Two hearts fused by some vile ritual. As each beats they strain against the bindings that hold them close to one another."
Chest

Max HP: +2

Luck: -1%

---
Sprite pickups organ soulreactorheart

Soul Reactor

"A heart split in two by a violent energetic reaction. It constantly forms, ruptures, and reforms again with each heartbeat."
Chest

Rate of Fire: +80%

Damage: -40%

Defeat the first emissary within the Insanity Portal.
Sprite pickups organ elinbergheart

Elinberg's Heart

"A heart torn from the battered husk of the Primal Id. A small portion of Professor Elinberg's essence is embedded inside. The final fate of the Professor is unknown, as this is the only physical remnant left behind."
Chest
30% damage boost after NOT dodging for 6 seconds.
Beat the game in Desecration 3
Sprite pickups organ biomechheart

Biomech Heart

"A strange heart reinforced with mechanical components. Twin pistons blast forth wicked energies at your foes."
Chest
Fire in a blast, deal extra damage.
---
Sprite pickups organ unstableheart

Unstable Heart

"An unstable beating heart. It causes your magic power to spray forth unbound by mortal focus."
Chest
Fire in a spray, deal extra damage.
---
Sprite pickups organ toxicpolyp

Toxic Polyp

"A small poisoned heart bearing malignant toxic pustules. Plauged ichor seeps out from within."
Chest
Fire a plauged bullet every 10 shots.
---
Sprite pickups organ icepiercedheart

Ice Pierced Heart

"An ice impaled heart nearly frozen solid. Your magic power may cause foes to slow much like this weary heart."
Chest
Fire a chilling bullet every 7 shots.
---
Sprite pickups organ bladedheart

Bladed Heart

"A brutal, bladed heart bound by bone and steel. It projects a forceful impact through your magic power."
Chest
Fire an impactful bullet every 10 shots.
---
Sprite pickups organ 08

Bilious Slimebag

"A foul sloshing sack of slime and rancid enzymes. You feel sick just looking at it, but somehow this pathetic looking stomach is a thriving, vital thing."
Guts

Max HP: -1

Damage: +0.2

Move Speed: +5%

Rate of Fire: +10%

---
Sprite pickups organ 43

Blinking Spleen

"A vile looking organ with an eye growing out of its surface. It gazes at you sympathetically."
Guts
Move Speed: +5%
---
Sprite pickups organ 03

Bloated Threadgut

"A writhing pile of indistinct masses bound by coiled and ropy tendons. It shifts uncomfortably and grabs at you."
Guts

Move Speed: +15%

Rate of Fire: -10%

---
Sprite pickups organ 37

Fetal Thing

"Some primitive unborn thing. It seems humanoid but you know it originated beyond your own world. It shuffles and swims about oblivious to your actions."
Guts

Luck: +2%

Ice Damage: +20%

Fire Damage: +20%

Plague Damage: +20%

Entropy Damage: +20%

Sample 20 different intestinal organs.
Sprite pickups organ 02

Robust Gut

"A hearty organ. It seems to be thriving despite being separated from it's original owner. When you hold it close it begins to pulse greedily."
Guts
Max HP: +1
---
Sprite pickups organ 09

Saint Athenabry's Guts

"The stomach and vital organs of Saint Athenabry. He spent his life in an attempt to bring logic and reason to the outer worlds where madness reigns. He was captured by a brutal warlord and sentenced to death by being crushed by a stampeding horde.
Guts

Max MP: +20

MP Regen: +0.1

Luck: -1%

---
Sprite pickups organ 33

Star Thing Egg Cluster

"A squirming collection of weird, fleshy spheres that pulse with light and resonant energy. How these things were born into this world or created, you can only speculate. You feel a protective urge coupled with deep intrinstic revulsion toward them."
Guts

Move Speed: +5%

Rate of Fire: +10%

MP Regen: +0.1

"Feel your blood filtered through two alien hearts and lungs simultaneously"
Sprite pickups organ 31

Yellowed Eel Guts

"A parasite colony that increases your metabolism. Separate snake like bodies writhe and tangle together in some symbolic union."
Guts
Plague Damage: +30%
---
Sprite pickups organ 10

Yellowed Fatty Spleen

"A greeny spleen that exudes a savory odor. It leaves a thick staining oil behind."
Guts

Damage: +0.4

Move Speed: -10%

---
Sprite pickups organ bejeweledspleen

Bejeweled Spleen

"A returned heirloom of Queen Umvorax's lost life. Someone had been carefully gliding her boned and stuffing embalmed organs into her handsome frame!"
Guts

Luck: +2%

Rate of Fire: +10%

---
Sprite pickups organ amphibianeggcluster

Amphiban Egg Cluster

"A cluster of eggs from some amphibian thing. The outer membrane eagerly clings to your skin."
Guts

Move Speed: +5%

Rate of Fire: +10%

---
Sprite pickups organ brutalgugstomach

Brutal Gug Stomach

"A vile organ from a mighty gug champion. You feel it twisting violently inside you."
Guts

Damage: -0.25

Damage: +10%

---
Sprite pickups organ fetalthingstarchild

Starchild Fetal Thing

"A fetal starchild calmly suspended in amniotic fluid. It peers out at you with a serene calm."
Guts

Damage: +0.1

Rate of Fire: +10%

Move Speed: +5%

Max MP: +10

---
Sprite pickups organ flagellumgut

Flagellum Gut

"A twisted, ropy organ, writhing and sliding about in a pool of its own secretions."
Guts
Move Speed: +10%
---
Sprite pickups organ gibberingbladder

Gibbering Bladder

"A fleshy, fluid filled sack covered in orifices. It tries to speak but chokes and leaks instead."
Guts

MP Regen: +0.1

Damage: +0.1

---
Sprite pickups organ opticgut

Optic Gut

"A strange organ with an eye on its surface. What strange purpose could an eye serve embedded inside a body?"
Guts

Luck: +1%

Black Eye: +10%

---
Sprite pickups organ slimyskull

Slimy Skull

"A gelid skull surrounded by some slimy macro-cell. You can sense a faint consciousness emanating from within..."
Guts

Luck: +2%

Rate of Fire: +10%

Ice Damage: +10%

Kill 200 Pink Slimes.
Sprite pickups organ toxinspore

Toxin Spore

"A branching fungal growth with deadly poison spores. At the end of each branch are pustules containing concentrated spore miasma."
Guts

Damage: +25%

Damage Taken: +1%

Plague Damage: +20%

Kill 50 Spore Muffins.
Sprite pickups organ unbornspider

Unborn Spider

"A branching fungal growth with deadly poison spores. At the end of each branch are pustules containing concentrated spore miasma."
Guts

Move Speed: +10%

Plague Damage: +30%

Kill 50 Spiderkin.
Sprite pickups organ toxicgut

Virulent Sputum

"This foul-smelling organ produces sputum that wildly spreads toxic disease."
Guts
Your plague is now exceptionally virulent.
Defeat the Master on Desecration 1 or higher.
Sprite pickups organ biomechgut

Biomechanical Gut

"A reeking, writhing stomach reinforced with mechanical components. Dual pistons blast out a foul spray at any who oppose you."
Guts

Damage: +20%

Max HP: +1

Fire in a blast, deal extra damage.

Defeat the second emissary within the Insanity Portal.
Sprite item relic alchemystone mercury

Alchemical Mercury

"This strange stone embodies the energetic spirit of Mercury. Any entropic force may be strengthened in presence of this stone."
Guts

Damage: +0.1

Entropy Damage: +120%

Dropped randomly by bosses in Endless Mode.
Sprite item relic alchemystone iron

Alchemical Iron

"This heavy stone embodies the warlike spirit of Iron. Explosive forces worthy of Mars itself become greater near this stone."
Guts

Damage: +0.1

Greatly increases the range of your explosions.

Dropped randomly by bosses in Endless Mode.
Sprite item relic alchemystone lead

Alchemical Lead

"This dull stone embodies a heavy spirit of Lead. Your spirit body can wield this dull, heavy weight as a weapon against foes."
Guts

Run into enemies to smash them.

Melee Damage +50%

Dropped randomly by bosses in Endless Mode.
Sprite item relic alchemystone sulphur

Alchemical Sulphur

"This strong smelling stone embodies a soul of Sulphur. The holy power innate in this soul now strikes fear in the hearts of its enemies."
Guts

Max HP: +1

Your Words of Wonder strike fear into the hearts of your foes

Dropped randomly by bosses in Endless Mode.
Sprite item relic alchemystone gold

Alchemical Gold

"This shimmering stone embodies a radiant spirit of Gold. Drink potions and exude the brillant power of the sun!
Guts

Rate of Fire: +10%

Potions now make you feel explosively unstable.

Dropped randomly by bosses in Endless Mode.
Sprite item relic alchemystone air

Alchemical Airstone

"This whispering stone embodies a quickling spirit of Air. Teleportation now brings forth a gale force of entropy to barrage your foes."
Guts

Rate of Fire: +10%

Move Speed: +5%

Teleporting now releases powerful entropic energy.

Dropped randomly by bosses in Endless Mode.
Sprite item relic alchemystone water

Alchemical Waterstone

"This damp stone embodies a chilling spirit of Water. Frigid forces of nature await to embolden your chilling and freezing powers."
Guts

Rate of Fire: +15%

Ice Damage: +30%

Your chills and freezes last twice as long.

Dropped randomly by bosses in Endless Mode.
Sprite item relic alchemystone fire

Alchemical Firestone

"This burning stone embodies a thermic spirit of Fire. It relishes in those who burn and may ignite a tempest of flame on your toes."
Guts

Rate of Fire: +15%

Fire Damage: +20%

Eruptions may occur whenever you deal fire damage.

Dropped randomly by bosses in Endless Mode.
Sprite item relic alchemystone earth

Alchemical Earthstone

"This sedimentary stone embodies a fundamental spirit of Earth. The gravity within can magnify the power of mortars with meteoric force."
Guts

Move Speed: +10%

Your mortars become meteors.

Dropped randomly by bosses in Endless Mode.
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